Analysis of Interactions between Telomeric i-Motif DNA and a Cyclic Tetraoxazole Compound
نویسندگان
چکیده
منابع مشابه
a phonological contrastive analysis of kurdish and english
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چکیده ندارد.
2′-Fluoroarabinonucleic acid modification traps G-quadruplex and i-motif structures in human telomeric DNA
Human telomeres and promoter regions of genes fulfill a significant role in cellular aging and cancer. These regions comprise of guanine and cytosine-rich repeats, which under certain conditions can fold into G-quadruplex (G4) and i-motif structures, respectively. Herein, we use UV, circular dichroism and NMR spectroscopy to study several human telomeric sequences and demonstrate that G4/i-moti...
متن کاملHuman telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix.
Human telomeric DNA composed of (TTAGGG/CCCTAA)n repeats may form a classical Watson-Crick double helix. Each individual strand is also prone to quadruplex formation: the G-rich strand may adopt a G-quadruplex conformation involving G-quartets whereas the C-rich strand may fold into an i-motif based on intercalated C*C+ base pairs. Using an equimolar mixture of the telomeric oligonucleotides d[...
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2018
ISSN: 1439-4227
DOI: 10.1002/cbic.201800425